Phenotypes Associated with This Genotype

Genotype
MGI:5451078

• Allelic Composition: Mirc33^tm1.1Cwh/Mirc33^tm1.1Cwh
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:189763 )

• life span is 12 months compared with 24 months for wild-type mice

immune system

thymus hypoplasia ( J:189763 )

abnormal T cell morphology ( J:189763 )

• ex vivo T cells exhibit increased activated proinflammatory T cell phenotype compared with wild-type cells

increased T-helper 1 cell number ( J:189763 )

• CD4+ T cells stimulation with polyclonal anti-CD3/anti-CD28 exhibit increased frequency of IFN-gamma expressing cells compared with wild-type cells

spleen hypoplasia ( J:189763 )

lymph node hypoplasia ( J:189763 )

• in untreated mice and mice treated with MOG peptide

lymphoid hypoplasia ( J:189763 )

• in untreated mice and mice treated with MOG peptide

increased interferon-gamma secretion ( J:189763 )

• from lymph node and spleen T cells ex vivo

increased interleukin-17 secretion ( J:189763 )

• from lymph node and spleen T cells ex vivo

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:189763 )

• MOG peptide-treated mice exhibit reduced experimental autoimmune encephalomyelitis severity with reduced CNS cellular infiltration compared with control mice

hematopoietic system

thymus hypoplasia ( J:189763 )

abnormal T cell morphology ( J:189763 )

• ex vivo T cells exhibit increased activated proinflammatory T cell phenotype compared with wild-type cells

increased T-helper 1 cell number ( J:189763 )

• CD4+ T cells stimulation with polyclonal anti-CD3/anti-CD28 exhibit increased frequency of IFN-gamma expressing cells compared with wild-type cells

spleen hypoplasia ( J:189763 )

endocrine/exocrine glands

thymus hypoplasia ( J:189763 )