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Phenotypes Associated with This Genotype
Genotype
MGI:5451030
Allelic
Composition
Ndufs4tm1Rpa/Ndufs4tm1Rpa
Genetic
Background
B6.129S4-Ndufs4tm1Rpa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndufs4tm1Rpa mutation (1 available); any Ndufs4 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• adults injected with adenoassociated virus expressing Cre-GFP to selectively inactive Ndufs4 in the vestibular nucleus exhibit increased mortality

growth/size/body
• adults injected with a Cre-expressing adenoassociated virus exhibit weight loss

nervous system
• adults injected with a Cre-expressing adenoassociated virus develop extensive microglial activation one month after injection

respiratory system
• adults injected with a Cre-expressing adenoassociated virus exhibit more irregular breathing than controls and occasional gasping as behavior deteriorates
• adults injected with a Cre-expressing adenoassociated virus exhibit a normal response to hypoxia but a blunted hypercapnic ventilator response

behavior/neurological
• adults injected with a Cre-expressing adenoassociated virus exhibit motor coordination deficits on the rotorod

hematopoietic system
• adults injected with a Cre-expressing adenoassociated virus develop extensive microglial activation one month after injection

immune system
• adults injected with a Cre-expressing adenoassociated virus develop extensive microglial activation one month after injection


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory