Phenotypes Associated with This Genotype

Genotype
MGI:5450841

• Allelic Composition: Serpina3g^tm1.1Arp/Serpina3g^tm1.1Arp
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:189782 )

• of CD44^hiCD8+ T cells in the absence of antigen stimulation

• of gp33+CD8+ T cells after LCMV infection

abnormal memory T cell morphology ( J:189782 )

• contain fewer intact lysosomes

decreased CD8-positive, alpha-beta memory T cell number ( J:189782 )

• fewer memory CD44^hiCD8+ T cells with age

• beginning at 16 weeks in the blood

• at 15 weeks in the bone marrow

• after 130 days of LCMV infection in the spleen and inguinal lymph nodes

• after successive infections

abnormal response to infection ( J:189782 )

• after LCMV infection, mice exhibit fewer CD8+ memory T cells compared with wild-type mice

hematopoietic system

decreased T cell proliferation ( J:189782 )

• of CD44^hiCD8+ T cells in the absence of antigen stimulation

• of gp33+CD8+ T cells after LCMV infection

abnormal memory T cell morphology ( J:189782 )

• contain fewer intact lysosomes

decreased CD8-positive, alpha-beta memory T cell number ( J:189782 )

• after successive infections

• fewer memory CD44^hiCD8+ T cells with age

• beginning at 16 weeks in the blood

• at 15 weeks in the bone marrow

• after 130 days of LCMV infection in the spleen and inguinal lymph nodes

cellular

decreased T cell proliferation ( J:189782 )

• of CD44^hiCD8+ T cells in the absence of antigen stimulation

• of gp33+CD8+ T cells after LCMV infection