Phenotypes Associated with This Genotype

Genotype
MGI:5450820

• Allelic Composition: Del(9Casp1-Casp4)1Bhk/Del(9Casp1-Casp4)1Bhk
• Genetic Background: 129-Del(9Casp1-Casp4)1Bhk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:189777 )

• macrophages are protected from very lose dose anthrax lethal toxin-induced pyroptosis

decreased interleukin-1 alpha secretion ( J:189777 )

• in macrophages exposed to LPS and anthrax lethal toxin

decreased interleukin-1 beta secretion ( J:189777 )

• in macrophages exposed to LPS and anthrax lethal toxin

• in macrophages exposed to titanium oxide with or without muramyl dipeptide or peptidoglycan

• in macrophages exposed to L18-muramyl dipeptide

homeostasis/metabolism

decreased lactate dehydrogenase level ( J:189777 )

• in macrophages exposed to anthrax lethal toxin

decreased susceptibility to injury ( J:189777 )

• mice are protected from anthrax toxin lethal toxin-induced lung inflammation with reduced inflammatory cell infiltrate, cell death, vascular permeability and chemokine levels compared with control mice

hematopoietic system

abnormal macrophage physiology ( J:189777 )

• macrophages are protected from very lose dose anthrax lethal toxin-induced pyroptosis