Phenotypes Associated with This Genotype

Genotype
MGI:5450805

• Allelic Composition: Il10ra^tm1.1Tlg/Il10ra^tm1.1Tlg; Tg(Cd4-cre)1Cwi/?
• Genetic Background: B6.Cg-Tg(Cd4-cre)1Cwi Il10ra^tm1.1Tlg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:189797 )

N • no abnormal phenotype is observed in mice in which autoimmune encephalitis has not been induced

decreased splenocyte proliferation ( J:189797 )

• less proliferation in culture of splenocytes collected 21 days after induction of autoimmune encephalitis

abnormal lymphocyte cell number ( J:189797 )

abnormal regulatory T cell number ( J:189797 )

• increased proportion of regulatory T cells early in the course of experimental autoimmune encephalitis

decreased T cell number ( J:189797 )

• decreased overall T cell accumulation during the course of experimental autoimmune encephalitis

autoimmune response ( J:189797 )

• autoimmune encephalitis induced by treatment with myelin oligodendrocyte glycoprotein peptide results in less severe disease than in controls

• time to initial symptoms similar to controls

• disease state is qualitatively similar to controls

• no mortality due to experimental autoimmune encephalitis

hematopoietic system

decreased splenocyte proliferation ( J:189797 )

• less proliferation in culture of splenocytes collected 21 days after induction of autoimmune encephalitis

abnormal lymphocyte cell number ( J:189797 )

abnormal regulatory T cell number ( J:189797 )

• increased proportion of regulatory T cells early in the course of experimental autoimmune encephalitis

decreased T cell number ( J:189797 )

• decreased overall T cell accumulation during the course of experimental autoimmune encephalitis

cellular

decreased splenocyte proliferation ( J:189797 )

• less proliferation in culture of splenocytes collected 21 days after induction of autoimmune encephalitis