Mouse Genome Informatics
tg
    Tg(SOD1*L126Z)#Deng/0
involves: C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• lifespan is on average 359 days

nervous system
• mutants exhibit extensive protein aggregates of the mutant protein in the gray matter of the spinal cord at 350 days of age
• mutants develop an amyotrophic lateral sclerosis-like phenotype by the age of 300-400 days, with an average onset of 336.3 days

Mouse Models of Human Disease
OMIM IDRef(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:109458