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Phenotypes Associated with This Genotype
Genotype
MGI:5449629
Allelic
Composition		 Kiss1tm1.1(cre/EGFP)Stei/Kiss1+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kiss1tm1.1(cre/EGFP)Stei mutation (1 available); any Kiss1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:178519 )
N
• Kiss1 neurons (neurons labeling for GFP) in the arcuate nucleui (ARC) of ovariectomized adult females express a hyperpolarization induced cation current (h current) and a transient Ca2+ current (T-type current) which are pacemaker currents, mRNA expression of Cnga1 (HCN) and Cacna1g (voltage-dependent calcium channel, T type, alpha 1G subunit) which underlie pacemaker currents, and show NMDA-induced burst firing activity; these data corroborate findings in the ARC of guinea pigs

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory