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Phenotypes Associated with This Genotype
Genotype
MGI:5449422
Allelic
Composition
Tg(SOD1*)DF7Yaw/Tg(SOD1*)DF7Yaw
Genetic
Background
C57BL/6-Tg(SOD1*)DF7Yaw
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean age of death is 126 +/- 16 days, earlier than in hemizygous mice

behavior/neurological
• phenotype is stated to be identical to hemizygous mice, however no data are presented
• phenotype is stated to be identical to hemizygous mice, however no data are presented

nervous system
• reactive gliosis in the spinal cord, predominantly in the lower spinal cord
• eosinophilic cytoplasmic inclusions are seen in the motor neurons that remain; inclusions resemble Lewy body-like hyaline inclusions, with the halo of inclusions composed of neurofilamentous structure and the core of granule-associated fibrils
• mean age of onset of motor neuron disease symptoms is 120 +/- 14 days, earlier than in hemizygotes
• loss of anterior horn cells in the spinal cord, predominantly in the lower spinal cord

muscle
• mean age of onset of disease symptoms is 120 +/- 14 days, earlier than in hemizygotes
• phenotype is stated to be identical to hemizygous mice, however no data are presented

skeleton
• phenotype is stated to be identical to hemizygous mice, however no data are presented

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:97932


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory