Phenotypes for Cdkn1b Vsx2 MGI:5449369 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cdkn1b^tm1Mlf/Cdkn1b⁺ Vsx2^tm1.1Eml/Vsx2^tm1.1Eml
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1b^tm1Mlf mutation (2 available); any Cdkn1b mutation (26 available)
Vsx2^tm1.1Eml mutation (0 available); any Vsx2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye morphology ( J:190452 )

• substantial improvements in tissue histology and retinal neurogenesis compared to mice homozygous for Vsx2^tm1.1Eml alone

• rescue in the peripheral region is not as strong as in the central region

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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