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Phenotypes Associated with This Genotype
Genotype
MGI:5448699
Allelic
Composition		 Akap5tm1Jsco/Akap5tm1Jsco
Tg(Ins2-cre)25Mgn/0
Genetic
Background		 involves: 129S * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap5tm1Jsco mutation (1 available); any Akap5 mutation (27 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased insulin secretion ( J:190017 )
• after intraperitoneal glucose injection in the pancreas
decreased circulating insulin level ( J:190017 )
• in fasting mice and after intraperitoneal glucose injection
impaired glucose tolerance ( J:190017 )
• despite normal insulin sensitivity

endocrine/exocrine glands
increased insulin secretion ( J:190017 )
• after intraperitoneal glucose injection in the pancreas

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory