Mouse Genome Informatics
tg
    Tg(SOD1*G85R)#Roos/0
involves: C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mean survival is 349 days

behavior/neurological
• progressive paralysis

growth/size
• weight loss begins at 307 days of age

nervous system
• in the anterior horn of the spinal cord at 350 days of age
• SOD1-immunoreactive aggregates (of mutant SOD1 homodimers) are seen in motor neuron cells in the anterior horn at 350 days of age
• loss of motor neurons at 350 days of age but not at 150 days of age

Mouse Models of Human Disease
OMIM IDRef(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:147156