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Phenotypes Associated with This Genotype
Genotype
MGI:5447982
Allelic
Composition		 Lef1tm1Hhx/Lef1tm1Hhx
Tcf7tm1Cle/Tcf7tm1Cle
Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+
Tg(GZMB-cre)1Jcb/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2Sho mutation (2 available); any Gt(ROSA)26Sor mutation (945 available)
Lef1tm1Hhx mutation (2 available); any Lef1 mutation (42 available)
Tcf7tm1Cle mutation (0 available); any Tcf7 mutation (24 available)
Tg(GZMB-cre)1Jcb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:189838 )
• decreased CD8+ effector T cells in the peripheral blood lymphocytes compared with control mice and more so than in Tcf7tm1Cle homozygotes following infection with actA- L. monocytogenes-expressing ovalbumin
• decreased memory precursors and memory CD8+ T cells compared with control mice and more so than in Tcf7tm1Cle homozygotes following infection with actA- L. monocytogenes-expressing ovalbumin
abnormal memory T cell physiology ( J:189838 )
• following infection with actA- L. monocytogenes-expressing ovalbumin, memory CD8+ T cells exhibit impaired maturation, function and recall response compared with control mice
decreased tumor necrosis factor secretion ( J:189838 )
• from CD8+ effector T cells following infection with actA- L. monocytogenes-expressing ovalbumin

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:189838 )
• decreased CD8+ effector T cells in the peripheral blood lymphocytes compared with control mice and more so than in Tcf7tm1Cle homozygotes following infection with actA- L. monocytogenes-expressing ovalbumin
• decreased memory precursors and memory CD8+ T cells compared with control mice and more so than in Tcf7tm1Cle homozygotes following infection with actA- L. monocytogenes-expressing ovalbumin
abnormal memory T cell physiology ( J:189838 )
• following infection with actA- L. monocytogenes-expressing ovalbumin, memory CD8+ T cells exhibit impaired maturation, function and recall response compared with control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory