Phenotypes Associated with This Genotype

Genotype
MGI:5447981

• Allelic Composition: Gt(ROSA)26Sor^tm2Sho/Gt(ROSA)26Sor⁺; Lef1^tm1Hhx/Lef1^tm1Hhx; Tg(GZMB-cre)1Jcb/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased CD8-positive, alpha-beta T cell number ( J:189838 )

• decreased CD8+ effector T cells in the peripheral blood lymphocytes compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin

• decreased CD8+ memory precursors and memory T cells compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin

abnormal memory T cell physiology ( J:189838 )

• following infection with actA- L. monocytogenes-expressing ovalbumin, memory CD8+ T cells exhibit impaired maturation, function and recall response compared with control mice

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:189838 )

• decreased CD8+ effector T cells in the peripheral blood lymphocytes compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin

• decreased CD8+ memory precursors and memory T cells compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin

abnormal memory T cell physiology ( J:189838 )

• following infection with actA- L. monocytogenes-expressing ovalbumin, memory CD8+ T cells exhibit impaired maturation, function and recall response compared with control mice