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Phenotypes Associated with This Genotype
Genotype
MGI:5447952
Allelic
Composition		 Chit1tm1Eli/Chit1tm1Eli
Tg(Scgb1a1-rtTA,tetO-CHIT1)#Eli/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chit1tm1Eli mutation (0 available); any Chit1 mutation (32 available)
Tg(Scgb1a1-rtTA,tetO-CHIT1)#Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:189872 )
• doxycycline-treated mice exhibit exacerbated bleomycin-induced pulmonary fibrosis compared with Tg(Scgb1a1-rtTA,tetO-CHIT1)#Eli mice
• however, bleomycin-induced inflammation is normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory