Phenotypes Associated with This Genotype

Genotype
MGI:5447726

• Allelic Composition: Cd5^tm1.1Chra/Cd5^tm1.1Chra; Tg(Tcra2D2,Tcrb2D2)1Kuch/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:189919 )

• in CD4+ T cells stimulated with anti-CD3

decreased T helper 1 cell number ( J:189919 )

• under nonpolarizing conditions

decreased interferon-gamma secretion ( J:189919 )

• in CD4+ T cells under nonpolarizing conditions

increased interferon-gamma secretion ( J:189919 )

• in CD4+ T cells stimulated with MOG35-55 compared with cells from wild-type control but not as much as in cells from Cd5^tm1Cgn/Cd5^tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice

increased interleukin-17 secretion ( J:189919 )

• in CD4+ T cells stimulated with MOG35-55 compared with cells from wild-type control but not as much as in cells from Cd5^tm1Cgn/Cd5^tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice

decreased interleukin-2 secretion ( J:189919 )

• IL2 levels from CD4+ T cells stimulated with MOG35-55 do not persist as long as in cells from wild-type mice

increased interleukin-6 secretion ( J:189919 )

• in CD4+ T cells stimulated with MOG35-55 compared with cells from wild-type control but not as much as in cells from Cd5^tm1Cgn/Cd5^tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice

hematopoietic system

decreased T cell proliferation ( J:189919 )

• in CD4+ T cells stimulated with anti-CD3

decreased T helper 1 cell number ( J:189919 )

• under nonpolarizing conditions

cellular

decreased T cell proliferation ( J:189919 )

• in CD4+ T cells stimulated with anti-CD3