Phenotypes Associated with This Genotype

Genotype
MGI:5447724

• Allelic Composition: Tg(Tcra2D2,Tcrb2D2)1Kuch/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell apoptosis ( J:189919 )

• under Th17 polarizing conditions

decreased T cell proliferation ( J:189919 )

• of CD4+ T cells stimulated with anti-CD3

increased T cell proliferation ( J:189919 )

• in CD4+ T cells stimulated with MOG35-55, rested then restimulated with MOG35-55 compared with cells from wild-type control and Cd5^tm1Cgn/Cd5^tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice

abnormal T-helper 1 cell number ( J:189919 )

• under nonpolarizing conditions, Th1 cells are reduced 50% compared to in wild-type but are 3-fold higher than in Cd5^tm1Cgn/Cd5^tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice

• in T cells cultures stimulated with MOG35-55

decreased T-helper 17 cell number ( J:189919 )

• 50% under Th17 polarizing conditions compared with wild-type control and Cd5^tm1Cgn/Cd5^tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice

• in T cells cultures stimulated with MOG35-55

decreased T-helper 2 cell number ( J:189919 )

• under Th2 polarizing conditions compared with wild-type controls and Cd5^tm1Cgn/Cd5^tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice

decreased interferon-gamma secretion ( J:189919 )

• in CD4+ T cells under nonpolarizing conditions

increased interferon-gamma secretion ( J:189919 )

• in CD4+ T cells stimulated with MOG35-55 compared with cells from wild-type control and Cd5^tm1Cgn/Cd5^tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice

decreased interleukin-10 secretion ( J:189919 )

• IL10 levels in T cells stimulated with MOG35-55 rise and contract unlike in cells from wild-type control and Cd5^tm1Cgn/Cd5^tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice where levels continue to rise

increased interleukin-17 secretion ( J:189919 )

• in CD4+ T cells stimulated with MOG35-55 compared with cells from wild-type control and Cd5^tm1Cgn/Cd5^tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice

decreased interleukin-2 secretion ( J:189919 )

• IL2 levels from T cells stimulated with MOG35-55 do not increase beyond day 1unlike in cells from wild-type control

increased interleukin-6 secretion ( J:189919 )

• in CD4+ T cells stimulated with MOG35-55 compared with cells from wild-type control and Cd5^tm1Cgn/Cd5^tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice

cellular

increased T cell apoptosis ( J:189919 )

• under Th17 polarizing conditions

decreased T cell proliferation ( J:189919 )

• of CD4+ T cells stimulated with anti-CD3

increased T cell proliferation ( J:189919 )

• in CD4+ T cells stimulated with MOG35-55, rested then restimulated with MOG35-55 compared with cells from wild-type control and Cd5^tm1Cgn/Cd5^tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice

hematopoietic system

increased T cell apoptosis ( J:189919 )

• under Th17 polarizing conditions

decreased T cell proliferation ( J:189919 )

• of CD4+ T cells stimulated with anti-CD3

increased T cell proliferation ( J:189919 )

• in CD4+ T cells stimulated with MOG35-55, rested then restimulated with MOG35-55 compared with cells from wild-type control and Cd5^tm1Cgn/Cd5^tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice

abnormal T-helper 1 cell number ( J:189919 )

• under nonpolarizing conditions, Th1 cells are reduced 50% compared to in wild-type but are 3-fold higher than in Cd5^tm1Cgn/Cd5^tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice

• in T cells cultures stimulated with MOG35-55

decreased T-helper 17 cell number ( J:189919 )

• 50% under Th17 polarizing conditions compared with wild-type control and Cd5^tm1Cgn/Cd5^tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice

• in T cells cultures stimulated with MOG35-55

decreased T-helper 2 cell number ( J:189919 )

• under Th2 polarizing conditions compared with wild-type controls and Cd5^tm1Cgn/Cd5^tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice