Phenotypes Associated with This Genotype

Genotype
MGI:5447722

• Allelic Composition: Cd5^tm1Cgn/Cd5^tm1Cgn
• Genetic Background: B6.129P2-Cd5^tm1Cgn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell proliferation ( J:189919 )

• in CD4+ T cells stimulated with anti-CD3 or cognate peptide, rested then restimulated with anti-CD3 or MOG35-55

• in CD8+ T cells when restimulated

increased regulatory T cell number ( J:189919 )

abnormal T cell anergy ( J:189919 )

• T cells treated with anti-CD3 or MOG35-55 are resistant to development of anergy

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:189919 )

• delayed onset and reduced severity of MOG-induced experimental autoimmune encephalomyelitis

hematopoietic system

increased T cell proliferation ( J:189919 )

• in CD4+ T cells stimulated with anti-CD3 or cognate peptide, rested then restimulated with anti-CD3 or MOG35-55

• in CD8+ T cells when restimulated

increased regulatory T cell number ( J:189919 )

cellular

increased T cell proliferation ( J:189919 )

• in CD4+ T cells stimulated with anti-CD3 or cognate peptide, rested then restimulated with anti-CD3 or MOG35-55

• in CD8+ T cells when restimulated