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Phenotypes Associated with This Genotype
Genotype
MGI:5447490
Allelic
Composition
Scn1atm2.1Wac/Scn1a+
Tg(I12b-cre)1Jlr/0
Genetic
Background
involves: C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn1atm2.1Wac mutation (1 available); any Scn1a mutation (49 available)
Tg(I12b-cre)1Jlr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice begin to die in the third postnatal week
• only 30% of mice survive to 90 days of age
• mice die 4-48 h after initial seizure onset

behavior/neurological
• spontaneous seizures are seen in about 1/3 of mice
• mice die 4-48 h after initial seizure onset
• elevation of body temperature induces seizure (mean temperature for seizure induction: 39.6 oC)
• seizures begin with forelimb clonus and progress in both frequency and severity through forelimb clonus with rearing
• seizures eventually culminate in generalized tonic-clonic seizure

nervous system
• spontaneous seizures are seen in about 1/3 of mice
• mice die 4-48 h after initial seizure onset
• elevation of body temperature induces seizure (mean temperature for seizure induction: 39.6 oC)
• seizures begin with forelimb clonus and progress in both frequency and severity through forelimb clonus with rearing
• seizures eventually culminate in generalized tonic-clonic seizure

Mouse Models of Human Disease
OMIM ID Ref(s)
Epileptic Encephalopathy, Early Infantile, 6; EIEE6 607208 J:189897


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory