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Phenotypes Associated with This Genotype
Genotype
MGI:5447480
Allelic
Composition		 Hspb2tm1.1Ijb/Hspb2tm1.1Ijb
Genetic
Background		 involves: 129S4/SvJaeSor * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hspb2tm1.1Ijb mutation (0 available); any Hspb2 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cellular respiration ( J:189659 )
• following transverse aortic constriction, mice exhibit reduced state 3 mitochondrial respiration and ATP production compared with controls
abnormal mitochondrial physiology ( J:189659 )
• following transverse aortic constriction, mice exhibit reduced state 3 mitochondrial respiration and ATP production compared with controls

cardiovascular system
cardiovascular system phenotype ( J:189659 )
N
• mice exhibit normal cardiac hypertrophic response to pressure overload

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory