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Phenotypes Associated with This Genotype
Genotype
MGI:5447473
Allelic
Composition
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(Pyy)Paba
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation (7 available); any Gt(ROSA)26Sor mutation (1031 available)
Gt(ROSA)26Sortm1(Pyy)Paba mutation (0 available); any Gt(ROSA)26Sor mutation (1031 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Lower bone mass and reduced bone size in Gt(ROSA)26Sortm1(Pyy)Paba/Gt(ROSA)26Sortm1(cre/ERT2)Tyj females

growth/size/body
• in females prior to tamoxifen treatment

skeleton
• in females after tamoxifen treatment
• decrease in vertebral height in females after tamoxifen treatment
• increase in osteoclast surface in the femoral metaphysis in tamoxifen treated males and females
• in tamoxifen treated females
• decreased bone mineral density in the femur of females after tamoxifen treatment
• in the distal femora and lumbar vertebrae in tamoxifen treated females
• in tamoxifen treated females
• decrease in the mineral apposition rate in the distal femoral metaphysis of tamoxifen treated males and females
• cancellous bone formation rate and mid-femoral endocortical MAR are decreased in tamoxifen treated females
• reduced mean polar moment of inertia in tamoxifen treated females

hematopoietic system
• increase in osteoclast surface in the femoral metaphysis in tamoxifen treated males and females
• in tamoxifen treated females

immune system
• increase in osteoclast surface in the femoral metaphysis in tamoxifen treated males and females
• in tamoxifen treated females

limbs/digits/tail
• in females after tamoxifen treatment


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/22/2025
MGI 6.24
The Jackson Laboratory