Phenotypes for Gt(ROSA)26Sor Notch1 Tg(Cdh5-cre)7Mlia MGI:5447168 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Notch1^tm1Agt/Notch1^tm1Agt Tg(Cdh5-cre)7Mlia/0 Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129 * 129S4/SvJaeSor * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (942 available)
Notch1^tm1Agt mutation (0 available); any Notch1 mutation (115 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal cardiac epithelial to mesenchymal transition ( J:189213 )

• arrested

abnormal atrioventricular cushion morphology ( J:189213 )

• at E10.5, atrioventricular cushions exhibit rounded endocardial-derived cells that accumulate at the cushion interface and less dense, hypoplastic areas unlike in control mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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