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Phenotypes Associated with This Genotype
Genotype
MGI:5446920
Allelic
Composition		 Rb1tm1Tyj/Rb1+
Trim27Gt(XP0484)Wtsi/Trim27Gt(XP0484)Wtsi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm1Tyj mutation (5 available); any Rb1 mutation (117 available)
Trim27Gt(XP0484)Wtsi mutation (0 available); any Trim27 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:189317 )
• as in Rb1tm1Tyj heterozygotes
increased pituitary gland tumor incidence ( J:189317 )
• as in Rb1tm1Tyj heterozygotes
increased thyroid tumor incidence ( J:189317 )
• as in Rb1tm1Tyj heterozygotes

endocrine/exocrine glands
increased pituitary gland tumor incidence ( J:189317 )
• as in Rb1tm1Tyj heterozygotes
increased thyroid tumor incidence ( J:189317 )
• as in Rb1tm1Tyj heterozygotes

nervous system
increased pituitary gland tumor incidence ( J:189317 )
• as in Rb1tm1Tyj heterozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory