Phenotypes Associated with This Genotype

Genotype
MGI:5446894

• Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw; Tcf21^tm1(cre)Seq/Tcf21⁺
• Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:189643 )

• embryos die at varying timepoints between E12.5 and birth

renal/urinary system

abnormal kidney morphology ( J:189643 )

• kidneys are comparable in size to controls, display numerous abnormal phenotypes

kidney cyst ( J:189643 )

• multiple cysts are observed, with some cysts containing glomeruli, with other cysts originating in the renal tubules

• cysts arise along entire nephron

abnormal kidney collecting duct morphology ( J:189643 )

• collecting ducts are dilated, distorted and winding, with increased cell proliferation in walls of cysts

abnormal kidney pelvis morphology ( J:189643 )

• pelvic area is dilated

neoplasm

increased tumor incidence ( J:189643 )

• lethality is suggested to result from an aggressive embryonic tumor with minimal renal invasion

growth/size/body

kidney cyst ( J:189643 )

• multiple cysts are observed, with some cysts containing glomeruli, with other cysts originating in the renal tubules

• cysts arise along entire nephron