Phenotypes Associated with This Genotype

Genotype
MGI:5446710

• Allelic Composition: Stag1^{Gt(P099A04)Wrst}/Stag1⁺
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:184720 )

premature aging ( J:184720 )

• some symptoms of premature aging including acute kyphosis

neoplasm

decreased incidence of tumors by chemical induction ( J:184720 )

• mice are resistant to 3-methyl-colanthrene-induced fibrosarcomas and diethyl-nitrosamine-induced liver tumors

decreased tumor growth/size ( J:184720 )

• reduced cell proliferation in 3-methyl-colanthrene-induced fibrosarcomas

increased tumor incidence ( J:184720 )

• reduced latency and altered tumor spectrum

• tumor incidence is not altered in Trp53 or Pten null backgrounds

increased lymphoma incidence ( J:184720 )

increased histiocytic sarcoma incidence ( J:184720 )

increased carcinoma incidence ( J:184720 )

• hepatocellular carcinoma and vascular carcinomas

increased hepatocellular carcinoma incidence ( J:184720 )

increased papilloma incidence ( J:184720 )

• cystic papillary neoplasm in the pancreas

cellular

abnormal telomere morphology ( J:184720 )

• intermediate fragile telomeres with defective telomere replication

abnormal mitosis ( J:184720 )

• increased frequency od defective anaphase in mouse embryonic fibroblasts and issues

decreased cell proliferation ( J:184720 )

• reduced cell proliferation in 3-methyl-colanthrene-induced fibrosarcomas

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:184720 )

• mice are resistant to 3-methyl-colanthrene-induced fibrosarcomas and diethyl-nitrosamine-induced liver tumors

skeleton

kyphosis ( J:184720 )

• acute

liver/biliary system

increased hepatocellular carcinoma incidence ( J:184720 )