Phenotypes Associated with This Genotype

Genotype
MGI:5446709

• Allelic Composition: Stag1^{Gt(P099A04)Wrst}/Stag1^{Gt(P099A04)Wrst}
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:184720 )

• no newborn mice are recovered

embryonic lethality during organogenesis, incomplete penetrance ( J:184720 )

• mice die between E11.5 and E12.5 with some surviving to E18.5

cellular

aneuploidy ( J:184720 )

• in mouse embryonic fibroblasts

abnormal telomere morphology ( J:184720 )

• fragile telomeres with defective telomere replication

abnormal mitosis ( J:184720 )

• defective chromosome segregation in mouse embryonic fibroblasts

decreased cell proliferation ( J:184720 )

• in cells from E18.5 embryos

decreased fibroblast proliferation ( J:184720 )

growth/size/body

abnormal tooth development ( J:184719 )

• delay in dendition at E17.5

decreased fetal size ( J:184719 , J:184720 )

• at E17.5 (J:184719)

• in cells from E18.5 embryos (J:184720)

adipose tissue

decreased brown adipose tissue amount ( J:184719 )

• reduced thickness at E17.5

decreased total body fat amount ( J:184719 )

• at E17.5

craniofacial

abnormal tooth development ( J:184719 )

• delay in dendition at E17.5

hematopoietic system

abnormal definitive hematopoiesis ( J:184719 )

• decreased number of hematopoietic precursors in the liver at E17.5

integument

decreased hair follicle number ( J:184719 )

• at E17.5

thin skin ( J:184719 )

• at E17.5

muscle

abnormal muscle morphology ( J:184719 )

• thin muscle layer at E17.5

renal/urinary system

abnormal kidney collecting duct morphology ( J:184719 )

• not radially arranged at E17.5

abnormal renal glomerulus morphology ( J:184719 )

• at E17.5, glomeruli are dispersed all over unlike in wild-type mice

skeleton

abnormal tooth development ( J:184719 )

• delay in dendition at E17.5

abnormal bone mineralization ( J:184719 )

• defective bone calcification in the cranium at E17.5

delayed intramembranous bone ossification ( J:184719 )

• in the cranium at E17.5