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Phenotypes Associated with This Genotype
Genotype
MGI:5446697
Allelic
Composition		 Il22tm1Flv/Il22tm1Flv
Il22ra2tm2Vlcg/Il22ra2tm2Vlcg
Genetic
Background		 involves: 129 * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il22ra2tm2Vlcg mutation (0 available); any Il22ra2 mutation (22 available)
Il22tm1Flv mutation (0 available); any Il22 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:189217 )
• tumor numbers in a colitis associated colon cancer model are decreased compared to mice homozygous for Il22ra2tm2Vlcg alone but increased compared to wild-type controls

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:189217 )
• tumor numbers in a colitis associated colon cancer model are decreased compared to mice homozygous for Il22ra2tm2Vlcg alone but increased compared to wild-type controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory