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Phenotypes Associated with This Genotype
Genotype
MGI:5446618
Allelic
Composition
Cacna1ctm1Ggm/Cacna1ctm1Ggm
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (37 available)
Cacna1ctm1Ggm mutation (0 available); any Cacna1c mutation (147 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• average survival time of 11.9 +/- 3 days following tamoxifen treatment for 5 days

cardiovascular system
• increase in ventricular end diastolic volume after tamoxifen treatment
• profound decrease in myocardial contractility, as assessed by fractional shortening, after tamoxifen treatment

muscle
• profound decrease in myocardial contractility, as assessed by fractional shortening, after tamoxifen treatment


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory