Phenotypes Associated with This Genotype

Genotype
MGI:5446170

• Allelic Composition: Klb^tm1.2Sakl/Klb^tm1.2Sakl; Tg(Apoe-Fgf21)1Sakl/0
• Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood homeostasis ( J:189018 )

• mice fed a high fat diet fail to exhibit changes in circulating triglyceride, cholesterol, leptin, adiponectin, insulin and glucose observed in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

decreased circulating free fatty acids level ( J:189018 )

• in mice fed a high fat diet but not as severe as in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

abnormal glucose homeostasis ( J:189018 )

• mice fed a high fat diet fail to exhibit improved glucose tolerance and insulin sensitivity observed in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

growth/size/body

abnormal lean body mass ( J:189018 )

• mice fail to exhibit altered body composition observed in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

decreased body weight ( J:189018 )

• not as severe as in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

adipose tissue

abnormal percent body fat/body weight ( J:189018 )

• mice fail to exhibit altered body composition observed in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

behavior/neurological

abnormal food intake ( J:189018 )

• mice fail to exhibit an increase in food intake observed in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

limbs/digits/tail

short tibia ( J:189018 )

• as in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

liver/biliary system

abnormal liver morphology ( J:189018 )

• mice fed a high fat diet fail to exhibit a decrease in liver weight and hepatic triglyceride and cholesterol levels observed in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

skeleton

short tibia ( J:189018 )

• as in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes