Phenotypes Associated with This Genotype

Genotype
MGI:5446167

• Allelic Composition: Klb^tm1.1Sakl/Klb^tm1.1Sakl; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:189018 )

• during a hyperinsulinemic-euglycemic clamp, mice fed a high fat diet and treated with FGF21 fail to exhibit an increase in glucose infusion rate and whole-body and brown adipose tissue glucose uptake or reduction in endogenous glucose production observed in FGF-treated control mice

increased insulin sensitivity ( J:189018 )

• mice fed standard chow or a high fat diet and treated with FGF21 exhibit improved insulin sensitivity compared with control mice

adipose tissue

abnormal adipose tissue physiology ( J:189018 )

• during a hyperinsulinemic-euglycemic clamp, mice fed a high fat diet and treated with FGF21 fail to exhibit an increase in brown adipose tissue glucose uptake observed in FGF-treated control mice