homeostasis/metabolism
• during a hyperinsulinemic-euglycemic clamp, mice fed a high fat diet and treated with FGF21 fail to exhibit an increase in glucose infusion rate and whole-body and brown adipose tissue glucose uptake or reduction in endogenous glucose production observed in FGF-treated control mice
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• mice fed standard chow or a high fat diet and treated with FGF21 exhibit improved insulin sensitivity compared with control mice
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adipose tissue
• during a hyperinsulinemic-euglycemic clamp, mice fed a high fat diet and treated with FGF21 fail to exhibit an increase in brown adipose tissue glucose uptake observed in FGF-treated control mice
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