Phenotypes Associated with This Genotype

Genotype
MGI:5446041

• Allelic Composition: Mex3c^{Gt(DD0642)Wtsi}/Mex3c^{Gt(DD0642)Wtsi}
• Genetic Background: FVB.129P2(B6)-Mex3c^{Gt(DD0642)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:189503 )

N • Background Sensitivity: more than 80% of mice lived to adulthood unlike mice on a congenic C57BL/6 background

skeleton

short tibia ( J:189503 )

abnormal long bone epiphyseal plate morphology ( J:189503 )

• the growth plate contains prehypertrophic stage chondrocytes unlike in wild-type mice

decreased width of hypertrophic chondrocyte zone ( J:189503 )

• with reduced mean height of terminal hypertrophic chondrocytes

decreased long bone epiphyseal plate size ( J:189503 )

homeostasis/metabolism

abnormal insulin-like growth factor I level ( J:189503 )

♀ • reduced in the bone of female mice at 6 to 7 weeks

decreased circulating insulin-like growth factor I level ( J:189503 )

• in female mice at 2 to 3 months

• in male mice at 5 months

growth/size/body

decreased body length ( J:189503 )

• in female mice at 5 months

• in male mice at 6 weeks

postnatal growth retardation ( J:189503 )

limbs/digits/tail

short tibia ( J:189503 )