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Phenotypes Associated with This Genotype
Genotype
MGI:5445935
Allelic
Composition
Scn5atm3(SCN5A*)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn5atm3(SCN5A*)Rdn mutation (0 available); any Scn5a mutation (62 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at 3 and 12 weeks, progressive with age
• spontaneous monomorphic and polymorphic ventricular tachycardia in 7 of 9 mice at 12 weeks
• in 5 mice
• at 3 and 12 weeks, progressive with age
• at 3 and 12 weeks, progressive with age
• at 3 and 12 weeks, progressive with age
• at 3 and 12 weeks, progressive with age
• myocytes exhibit decreased action potential amplitude, decreased peak sodium current and prolonged action potential duration compared with cells from wild-type mice

muscle

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy 1E DOID:0110433 OMIM:601154
J:189389


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory