Phenotypes Associated with This Genotype

Genotype
MGI:5445701

• Allelic Composition: Slc2a8^tm1Khm/Slc2a8^tm1Khm
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased litter size ( J:189148 )

homeostasis/metabolism

abnormal homeostasis ( J:189148 )

• mice fed a high fructose diet exhibit worsened metabolic syndrome-like state compared with wild-type mice

abnormal blood homeostasis ( J:189148 )

• mice fed a high fructose diet exhibit increased serum fructose concentration compared with wild-type mice

• however, glucose uptake is normal

increased circulating insulin level ( J:189148 )

• in fasting mice fed a high fructose diet

increased circulating cholesterol level ( J:189148 )

• in mice fed a high fructose diet

increased circulating LDL cholesterol level ( J:189148 )

• in mice fed a high fructose diet

cardiovascular system

increased systemic arterial diastolic blood pressure ( J:189148 )

• in mice fed a high fructose diet

increased systemic arterial systolic blood pressure ( J:189148 )

• in mice fed a high fructose diet

digestive/alimentary system

abnormal intestinal fructose absorption ( J:189148 )

• enhanced jejunal fructose uptake in mice fed a high fructose diet

• however, reconstitution of Slc2a8 normalizes fructose uptake

growth/size/body

decreased body weight ( J:189148 )

• mild at 22 weeks in mice fed standard chow