Phenotypes Associated with This Genotype

Genotype
MGI:5444886

• Allelic Composition: Tcf7l2^tm1Geno/Tcf7l2^tm1Geno; Tg(Pdx1-cre)89.1Dam/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:189204 )

• at 20 weeks in glucose and GLP-1-stimulated islets

increased circulating insulin level ( J:189204 )

• at 20 weeks after intraperitoneal injection of glucose

impaired glucose tolerance ( J:189204 )

• at 12 weeks upon oral glucose challenge

• at 20 weeks upon intraperitoneal injection of glucose

• in mice fed a high fat diet upon intraperitoneal injection of glucose

endocrine/exocrine glands

decreased pancreatic beta cell mass ( J:189204 )

• in mice fed a high fat diet

decreased insulin secretion ( J:189204 )

• at 20 weeks in glucose and GLP-1-stimulated islets