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Phenotypes Associated with This Genotype
Genotype
MGI:5444716
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt11tm1Amc/Wnt11+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (32 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)
Wnt11tm1Amc mutation (3 available); any Wnt11 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 100% of embryos (n=10) display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs

craniofacial
cleft palate ( J:189062 )
• in 11% of embryos (n=9)

digestive/alimentary system
cleft palate ( J:189062 )
• in 11% of embryos (n=9)

growth/size/body
cleft palate ( J:189062 )
• in 11% of embryos (n=9)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory