Phenotypes Associated with This Genotype

Genotype
MGI:5444706

• Allelic Composition: Fzd2^tm1.1Nat/Fzd2⁺; Fzd7^tm1.1Nat/Fzd7^tm1.1Nat
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:189062 )

• more than 50% die postnatally

• survivors are viable and fertile

cardiovascular system

abnormal heart morphology ( J:189062 )

• 50% of embryos (n=22) display cardiac defects

double outlet right ventricle ( J:189062 )

• DORV in combination with a ventricular septal defect is occasionally seen

ventricular septal defect ( J:189062 )

craniofacial

craniofacial phenotype ( J:189062 )

N • Background Sensitivity: no palate closure defects are detected in mice on a mixed strain background including 129 and C57BL/6; however, palate closure defects are seen in mice on a mixed strain background including 129, C57BL/6 and LPT/LeJ