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Phenotypes Associated with This Genotype
Genotype
MGI:5444484
Allelic
Composition
Tgfb2tm1Doe/Tgfb2+
Genetic
Background
STOCK Tgfb2tm1Doe/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfb2tm1Doe mutation (2 available); any Tgfb2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• elastic fiber fragmentation and greater collagen deposition within the medial compartment of the aortic wall is increased compared to wild-type mice
• by 8 months of age, heterozygotes show dilation of the aortic annulus and root
• however, dimensions of the more distal ascending aorta are normal
• aortic root aneurysm

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Loeys-Dietz syndrome DOID:0050466 J:188799


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory