About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5444200
Allelic
Composition
Grntm1.1Far/Grntm1.1Far
Genetic
Background
involves: 129S4/SvJae * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grntm1.1Far mutation (1 available); any Grn mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased 3-fold in MPTP-treated mice
• from microglia exposed to LPS and IFN-gamma
• from microglia exposed to LPS and IFN-gamma
• from microglia exposed to LPS and IFN-gamma
• from microglia exposed to LPS and IFN-gamma

vision/eye
• levels of nuclear TDP-43 is reduced in retinal ganglion cell layer neurons of 18 month old mutants, whereas levels of cytoplasmic TDP-43 are unchanged
• depletion of nuclear TDP-43 also occurs in 12 month old mice before significant retinal ganglion cell layer neuron loss
• neither nuclear nor cytoplasmic TDP-43 inclusions are seen in retinal ganglion cell layer neurons
• loss of ganglion cell layer cells in 18 month old mutants
• progressive thinning of the retinal nerve fiber layer
• age-dependent reduction in a wave amplitude
• age-dependent reduction in b wave amplitude
• mutants have reduced amplitudes of photopic negative responses at 18, but not 12, months of age

nervous system
• increased 3-fold in MPTP-treated mice
• greater in mice treated with MPTP compared with control mice
• levels of nuclear TDP-43 is reduced in retinal ganglion cell layer neurons of 18 month old mutants, whereas levels of cytoplasmic TDP-43 are unchanged
• depletion of nuclear TDP-43 also occurs in 12 month old mice before significant retinal ganglion cell layer neuron loss
• neither nuclear nor cytoplasmic TDP-43 inclusions are seen in retinal ganglion cell layer neurons
• retinal neurodegeneration
• loss of ganglion cell layer cells in 18 month old mutants
• culture media conditioned with microglia exposed to LPS and IFN-gamma can induce increased cell death in wild-type neurons (J:188324)
• primary cortical neurons grown in culture exhibit shorter survival than wild-type neurons (J:218705)

homeostasis/metabolism

cellular

hematopoietic system
• increased 3-fold in MPTP-treated mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/09/2019
MGI 6.14
The Jackson Laboratory