Phenotypes for Dkk3 Kcnk3 MGI:5444118 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dkk3^tm1Cni/Dkk3^tm1Cni Kcnk3^tm1Sgb/Kcnk3^tm1Sgb
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk3^tm1Cni mutation (1 available); any Dkk3 mutation (28 available)
Kcnk3^tm1Sgb mutation (1 available); any Kcnk3 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating aldosterone level ( J:188335 )

• females and males have severely increased plasma aldosterone levels under basal conditions

• potassium-rich diet does not further increase plasma aldosterone levels

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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