Phenotypes Associated with This Genotype

Genotype
MGI:5443840

• Allelic Composition: Erg^tm2Poet/Erg^tm2Poet
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:188920 )

• no live embryos are detected beyond E11.5

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:188920 )

• capillaries ware collapsed at E10.5

abnormal vascular development ( J:188920 )

• decrease in vascularization at E11.5

abnormal developmental vascular remodeling ( J:188920 )

• large arborized vessels that are characteristic of vascular plexus remodeling are completely absent

• at E10.5, the primary plexus is present but vessels fail to fuse to form larger vessels

• at E10.5, in the brain the alignment and invasion of vessels from the perineural vascular plexus into the developing ganglionic eminence are abnormal

abnormal heart development ( J:188920 )

• invasion of the mesenchyme is dramatically decreased during valve morphogenesis

pericardial effusion ( J:188920 )

• at E10.5

internal hemorrhage ( J:188920 )

• in the head and/or trunk

intracranial hemorrhage ( J:188920 )

embryo

abnormal placental labyrinth vasculature morphology ( J:188920 )

• capillaries ware collapsed at E10.5

decreased embryo size ( J:188920 )

• at E9.5 - E11.5

nervous system

intracranial hemorrhage ( J:188920 )

growth/size/body

decreased embryo size ( J:188920 )

• at E9.5 - E11.5

homeostasis/metabolism

pericardial effusion ( J:188920 )

• at E10.5