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Phenotypes Associated with This Genotype
Genotype
MGI:5442795
Allelic
Composition		 Slamf8tm1Mill/Slamf8tm1Mill
Genetic
Background		 involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slamf8tm1Mill mutation (0 available); any Slamf8 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:188963 )
• in response to E. coli or S. aureus exposure or treatment with PMA, macrophage exhibit high NADPH oxidase enzyme activity and phagosomal acidification compared with cells from wild-type mice
increased susceptibility to bacterial infection ( J:188963 )
• in response to E. coli or S. aureus exposure or treatment with PMA, macrophage exhibit high NADPH oxidase enzyme activity and phagosomal acidification compared with cells from wild-type mice

hematopoietic system
abnormal macrophage physiology ( J:188963 )
• in response to E. coli or S. aureus exposure or treatment with PMA, macrophage exhibit high NADPH oxidase enzyme activity and phagosomal acidification compared with cells from wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory