Analysis Tools
renal/urinary system
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• at E12.25, only 12.5% of ureters have begun to separate from their corresponding mesonephric ducts relative to 70% of wild-type ureters, indicating a delay in ureter maturation
• at E14, 25% of ureters remain attached to the mesonephric duct relative to 6.25% of wild-type controls
• at E17, all ureters have independent openings into the bladder; however, their entry is at a less oblique angle relative to that in wild-type controls
• at E17, only 18% of embryos have ureters that enter the bladder at an oblique angle relative to 69% of wild-type controls
• no differences in crown-rump lengths are observed, suggesting a urinary tract specific delay
• delay in ureter maturation is not due to a altered apoptosis in the common nephric duct or surrounding tissues at E11
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• at E10.25, some ureteric buds display irregular contours relative to wild-type controls
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• at E11.25 and E13, reduced ureteric bud branching may be observed in embryos with a duplex collecting system
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• at E10.25, embryos exhibit more caudally positioned ureteric buds relative to wild-type controls
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