Phenotypes Associated with This Genotype

Genotype
MGI:5442376

• Allelic Composition: Hnrnpl^tm1.1Tmo/Hnrnpl^tm1.1Tmo; Tg(Lck-cre)548Jxm/0
• Genetic Background: B6.Cg-Hnrnpl^tm1.1Tmo Tg(Lck-cre)548Jxm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell proliferation ( J:188749 )

• in DN4 and CD4SP cells following the TCR beta selection checkpoint

thymus hypoplasia ( J:188749 )

• 75% reduction, cell-autonomous

abnormal T cell differentiation ( J:188749 )

• thymocyte chemotaxis is impaired

increased double-negative T cell number ( J:188749 )

• slight

decreased double-positive T cell number ( J:188749 )

decreased T cell number ( J:188749 )

• reduction is specific to TCR alpha-beta cells

• in the periphery

• however, the number of gamma-delta cells is normal

decreased CD4-positive, alpha-beta T cell number ( J:188749 )

• in the thymus

decreased CD8-positive, alpha-beta T cell number ( J:188749 )

• in the thymus

hematopoietic system

increased T cell proliferation ( J:188749 )

• in DN4 and CD4SP cells following the TCR beta selection checkpoint

thymus hypoplasia ( J:188749 )

• 75% reduction, cell-autonomous

abnormal T cell differentiation ( J:188749 )

• thymocyte chemotaxis is impaired

increased double-negative T cell number ( J:188749 )

• slight

decreased T cell number ( J:188749 )

• reduction is specific to TCR alpha-beta cells

• in the periphery

• however, the number of gamma-delta cells is normal

decreased double-positive T cell number ( J:188749 )

decreased CD4-positive, alpha-beta T cell number ( J:188749 )

• in the thymus

decreased CD8-positive, alpha-beta T cell number ( J:188749 )

• in the thymus

endocrine/exocrine glands

thymus hypoplasia ( J:188749 )

• 75% reduction, cell-autonomous

cellular

increased T cell proliferation ( J:188749 )

• in DN4 and CD4SP cells following the TCR beta selection checkpoint