Phenotypes Associated with This Genotype

Genotype
MGI:5442319

• Allelic Composition: Sec63^tm1Som/Sec63^tm1Som; Tg(Cdh16-cre)91Igr/0
• Genetic Background: involves: 129 * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:188763 )

• by P60 associated with kidney cysts

renal/urinary system

kidney cyst ( J:188763 )

• mild at P14, advanced at P30 and severe at P69

• collecting ducts form large cysts

• however, expression of Tg(Pdk1)248Som slows development of cystic kidney phenotype

dilated kidney collecting duct ( J:188763 )

abnormal loop of Henle ascending limb thick segment morphology ( J:188763 )

• dilated to a lesser extent than collecting tubules

homeostasis/metabolism

increased blood urea nitrogen level ( J:188763 )

growth/size/body

kidney cyst ( J:188763 )

• mild at P14, advanced at P30 and severe at P69

• collecting ducts form large cysts

• however, expression of Tg(Pdk1)248Som slows development of cystic kidney phenotype