Phenotypes Associated with This Genotype

Genotype
MGI:5441352

• Allelic Composition: Evc^tm1Jago/Evc^tm1Jago; Evc2^tm1.1Vlrp/Evc2^tm1.1Vlrp
• Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:188176 )

skeleton

impaired osteoblast differentiation ( J:188176 )

• in the perichondrium

basisphenoid bone foramen ( J:188176 )

abnormal presphenoid synchondrosis ( J:188176 )

• defects in the intrasphenoidal synchondrosis

abnormal long bone epiphyseal plate morphology ( J:188176 )

• most mice exhibit an ectopic protrusion of cartilage in the boundary between proliferating and hypertrophic chondrocytes in the proximal growth plate of the radius

abnormal long bone epiphyseal plate proliferative zone ( J:188176 )

• reduced

short ribs ( J:188176 )

abnormal chondrocyte physiology ( J:188176 )

• decreased proliferation in the growth plate

cellular

impaired osteoblast differentiation ( J:188176 )

• in the perichondrium

craniofacial

basisphenoid bone foramen ( J:188176 )

abnormal presphenoid synchondrosis ( J:188176 )

• defects in the intrasphenoidal synchondrosis

limbs/digits/tail

short limbs ( J:188176 )