Phenotypes Associated with This Genotype

Genotype
MGI:5441350

• Allelic Composition: Evc2^tm1.1Vlrp/Evc2^tm1.1Vlrp
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:188176 )

skeleton

impaired osteoblast differentiation ( J:188176 )

• at the leading edge of the bone collar

abnormal basicranium morphology ( J:188176 )

• in the frontal region

short radius ( J:188176 )

short femur ( J:188176 )

short tibia ( J:188176 )

abnormal long bone epiphyseal plate morphology ( J:188176 )

• most mice exhibit an ectopic protrusion of cartilage in the boundary between proliferating and hypertrophic chondrocytes in the proximal growth plate of the radius

abnormal long bone epiphyseal plate proliferative zone ( J:188176 )

• reduced

decreased width of hypertrophic chondrocyte zone ( J:188176 )

short ribs ( J:188176 )

abnormal chondrocyte physiology ( J:188176 )

• decreased proliferation in the resting zone of the growth plate

• delayed hypertrophy of chondrocytes adjacent to the perichondrium

cellular

impaired osteoblast differentiation ( J:188176 )

• at the leading edge of the bone collar

craniofacial

abnormal basicranium morphology ( J:188176 )

• in the frontal region

limbs/digits/tail

short radius ( J:188176 )

short femur ( J:188176 )

short tibia ( J:188176 )

short limbs ( J:188176 )

• progressive proximodistal shortening