Phenotypes Associated with This Genotype

Genotype
MGI:5441218

• Allelic Composition: Rela^tm1Rsch/Rela^tm1Rsch; Tg(Lck-cre)I57Jxm/0
• Genetic Background: involves: ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal gamma-delta T cell morphology ( J:169863 )

• reduced IL17-expressing splenic gamma-delta T cells and Vgamma4 gamma-delta T cells

immune system

immune system phenotype ( J:169863 )

N • alpha-beta Th17 cell differentiation is normal

abnormal gamma-delta T cell morphology ( J:169863 )

• reduced IL17-expressing splenic gamma-delta T cells and Vgamma4 gamma-delta T cells

decreased interleukin-17 secretion ( J:169863 )

• in the peritoneal cavity of E. coli-infected mice

• in TCRbeta+CD4+CD44^hi thymocytes

increased susceptibility to bacterial infection ( J:169863 )

• mice infected with E. coli exhibit reduced peritoneal neutrophils and IL17 in the peritoneal cavity compared with control mice