Phenotypes Associated with This Genotype

Genotype
MGI:5441042

• Allelic Composition: Smn1^{tm5(Smn1/SMN2)Mrph}/Smn1^{tm6(SMN2)Mrph}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

tail necrosis ( J:186987 )

• onset of tail necrosis (tail swelling and shortening) occurs at 6 weeks of age

integument

epidermal necrosis ( J:186987 )

• mutants present with progressive necrosis of peripheral body parts beginning with the tail and moving toward the hindlimbs and then to the pinnae of the ears