Phenotypes Associated with This Genotype

Genotype
MGI:5440873

• Allelic Composition: \Pcdhg^tm1.1Tman/\Pcdhg^tm1.1Tman
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:188341 )

• during the first day after birth

behavior/neurological

abnormal reflex ( J:188341 )

• compromised

tremors ( J:188341 )

• limb tremors

hunched posture ( J:188341 )

abnormal voluntary movement ( J:188341 )

• compromised

nervous system

astrocytosis ( J:188341 )

microgliosis ( J:188341 )

increased neuron apoptosis ( J:188341 )

• in the spinal cord

neuron degeneration ( J:188341 )

• mice exhibit severe neuronal loss in the ventral horn (70%), deep dorsal horn (50%) and superficial dorsal horn (30%) in the spinal cord compared with wild-type mice

muscle

muscle hypertonia ( J:188341 )

cellular

astrocytosis ( J:188341 )

microgliosis ( J:188341 )

increased neuron apoptosis ( J:188341 )

• in the spinal cord

embryo

umbilical hernia ( J:188341 )

hematopoietic system

microgliosis ( J:188341 )

immune system

microgliosis ( J:188341 )