Analysis Tools
nervous system
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• at 1 year, mice exhibit axonal pathology and repair with increased number of Schmidt-Lanterman incisures, myelin corrugation, infoldings and outfoldings and fibers with increased myelin thickness, density of axoplasm, axonal swelling and degeneration, and neurofilament density
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• at 1 year, mice exhibit decreased sciatic motor amplitude compared with control mice
• however, mice exhibit normal tail motor and orthodromic tail sensory amplitudes and conduction velocity
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behavior/neurological
| N |
• at 1 year, mice exhibit normal locomotor activity and strength
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growth/size/body
| N |
• at 1 year, mice exhibit normal body weight
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