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Phenotypes Associated with This Genotype
Genotype
MGI:5440289
Allelic
Composition
Tg(RHO-P23H)DTpd/?
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• attenuation of retinal blood vessels
• similar to human eyes with retinitis pigmentosa
• moderate thinning at 10 days of age
• marked photoreceptor degeneration by 20 days of age
• outer nuclear layer reduced to a single layer of sparse photoreceptor nuclei
• inner layers normal
• flat hyper- and hypo-pigmented areas unlike dendritic clumps found in human disease
• retinal pigment epithelial cells variable in height and melanin content
• reduced a and b wave amplitudes in electroretinograms
• delayed b wave response times

cardiovascular system
• attenuation of retinal blood vessels
• similar to human eyes with retinitis pigmentosa

pigmentation
• flat hyper- and hypo-pigmented areas unlike dendritic clumps found in human disease
• retinal pigment epithelial cells variable in height and melanin content

nervous system
• moderate thinning at 10 days of age
• marked photoreceptor degeneration by 20 days of age
• outer nuclear layer reduced to a single layer of sparse photoreceptor nuclei
• inner layers normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 4 DOID:0110372 OMIM:613731
J:76722


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory